Application | Comment | Organism |
---|---|---|
medicine | inhibition of mPGES-1 may have clinical utility in the management of bone cancer pain | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Lewis lung carcinoma cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Mus musculus | Prostaglandin E2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
microsomal prostaglandin E synthase-1 | - |
Mus musculus |
mPGES-1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | PGES-1-deficient mice exhibit reduced tumor growth in bone marrow and significantly fewer spontaneous flinches and their onset is several days later compared to wild type mice | Mus musculus |
physiological function | microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice | Mus musculus |